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“Additional clinical trials, along with ours, now show that patients with chronic joint pain who take an adequate amount of natural purified fish oil, for a long enough period of time, can get meaningful relief without relying on medications.” --> Omega-3 is a powerful anti-inflammatory...Omega-3, through its active ingredients EPA and DHA, inhibit the proinflammatory interleukins (IL-1, IL-6, and IL-12), tumor necrosis factor alpha, and the two series of inflammatory prostaglandins. New research is furthering our knowledge by which Omega-3s work their anti-inflammatory powers. In 2005, researchers at Brigham and Women’s Hospital and Harvard Medical School identified a new class of fats in humans, derived from a fatty acid found in fish oil, which they showed can control inflammation.1 The team concluded that Omega-3 has therapeutic benefits with inflammation: "Clinical assessment of dietary supplementation with Omega-3 polyunsaturated fatty acids indicate their beneficial impact in certain human diseases, particularly those in which inflammation is suspected as a key component in pathogenesis." Lead Harvard researcher Dr. Charles Serhan was quoted after the study: "Since we obtained these results I started to encourage my own children to eat foods rich in omega-3 fatty acids." While Omega-3 performs anti-inflammatory activities in the body, Omega-6, on the other hand, largely does the opposite (fires up the immune system and inflammatory response). --> Our diets today are drowning in Omega-6 relative to Omega-3...For over a million years, humans evolved on a diet rich in natural Omega-3 food sources such as fish, nuts, and free-range game. As a result, our Omega-3 (anti-inflammatory) and Omega-6 (pro-inflammatory) fatty acids were in close balance with one another, about a 2:1 ratio. In the last 100 years or so, our diets have changed remarkably with the advent of industrialization. We now consume manufactured corn, soybean, and safflower oils (Omega-6 sources) and much less fish and wild game (Omega-3 sources). Due to our drastic change in diet, we now observe about a 25:1 ratio, whereby our pro-inflammatory Omega-6 fatty acids dominate over our anti-inflammatory Omega-3 fatty acids. It should therefore come us little surprise that cultures with high diet intakes of fish rich in Omega-3 such as the Eskimos and Japanese have a low incidence of chronic inflammatory disorders even when compared to their Westernized ethnic counterparts.2 Observant of these interesting correlations, modern science has put Omega-3 to the test through hundreds of clinical studies across a range of diseases. --> Recent Omega-3 study shows promising results for back and neck pain...In 2005, neurosurgeons at the University of Pittsburgh Medical Center conducted a study with 250 patients with nonsurgical neck and back pain.3 All the patients were asked to take 2.4 grams daily of Omega-3 for two weeks and then drop to 1.2 grams daily. A questionnaire was sent one month after starting the supplement and 125 patients responded. The study was published in the peer-reviewed medical journal, Surgical Neurology, and it won first prize in the poster competition at the American Association of Neurological Surgeons (AANS) annual meeting in 2005. The results from the study were very positive. Patients reported improvement in overall pain, decreased joint pain, high satisfaction with Omega-3, and a significant reduction in NSAIDs and other pain medications:
There were no significant side effects reported except for two patients who reported loose bowel movements. The lead researchers of the study conclude:
"Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. Omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group." Although very promising, the study only serves as a starting point for Omega-3 and back and neck pain since it was retrospective and non-placebo controlled. However, patients with other inflammatory disorders, such as rheumatoid arthritis, have participated in numerous double-blind placebo controlled trials. Similar to this back and neck study, these placebo-controlled trials also show that Omega-3 can reduce joint pain and reduce NSAID use. --> OMAPURE™'s main ingredient, Omega-3, may allow a reduced use of NSAIDs (non steroidal anti-inflammatory drugs)...The very serious side effects of NSAIDs, including ibuprofen (Advil), naproxen (Aleve), and celecoxib (Celebrex), are well-known. More than 100,000 people in the US are hospitalized and nearly 20,000 patients die of complications related to the use of NSAIDs for the treatment of pain and inflammation, now making NSAIDS the most common cause of drug-related morbidity and mortality reported to the FDA. The respected Mayo Clinic states: "NSAIDs can cause stomach ulcers and related conditions.The FDA is now requiring expanded information about the risk of gastrointenstinal bleeding on the labels.Large dosages of NSAIDs can also lead to kidney problems and fluid retention, which can worsen congestive heart failure." Omega-3 is a natural COX inhibitor and has a much safer profile than NSAIDs. Leading scientific researchers explain: "Fish oils contain the natural COX inhibitor EPA, which inhibits both COX-1 and COX-2 activity. The different effects of EPA and NSAIDs on synthesis of downstream products are consistent with the known cardioprotective effect of fish oil and increased cardiovascular risk associated with NSAIDs (especially those that are COX-2 selective)." The same researchers conclude from the clinical literature that Omega-3 can reduce NSAID use: "Fish oils have been shown to reduce discretionary NSAID use for analgesia by about 50%."4 One study published in the highly regarded peer reviewed journal Arthritis & Rheumatism found that some Rheumatoid Arthritis (RA) patients could not only reduce NSAID use but also eliminate it: "We believe that our data support the previous observations that selected individuals with RA may discontinue NSAID therapy while consuming Omega 3 supplements."5 We invite you to read more on Omega-3 and its potential as a safer alternative to NSAIDs. --> Omega-3 also brings you other important benefits...Perhaps the most widely known health benefits for Omega-3 involve the heart. Omega-3 supplementation can reduce the risk of heart attack. The American Heart Association states: "Evidence from prospective secondary prevention studies suggests that EPA+DHA (Omega-3's active ingredients) supplementation ranging from 0.5 to 1.8 g/d (either as fatty fish or supplements) significantly reduces subsequent cardiac and all-cause mortality."6
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